League of Legends Vayne Guide: Best Build, Runes, Combos

Vayne is one of the deadliest ADCs in League of Legends, known for her insane mobility, true damage, and unmatched late-game potential. If you’re looking to carry games solo, Vayne can be your best pick—especially against tank-heavy teams. This guide covers the best build, runes, items, and combos to help you get the most out of her kit and climb the ranks with confidence.

Vayne Abilities Overview In League of Legends

Vayne’s kit is built around high mobility, dueling power, and melting down even the tankiest enemies. Her passive, Night Hunter, gives bonus movement speed when chasing enemy champions. Her Q, Tumble, is a short dash that empowers her next basic attack—useful for dodging skillshots or repositioning. Her W, Silver Bolts, is her core damage ability, dealing bonus true damage every third hit on the same target. Her E, Condemn, knocks enemies back and stuns them if they hit a wall—great for picks or escaping danger. Finally, her ultimate, Final Hour, boosts her damage, grants stealth on Tumble, and enhances Night Hunter—making her a terrifying force in teamfights and duels.

Best Summoner Spells For Vayne

The best summoner spells for Vayne are Flash and Heal. Flash gives her the mobility to escape or reposition in fights, which is crucial for a squishy ADC. Heal provides sustain and a burst of movement speed during trades or teamfights, helping her survive all-ins or turn fights around. If you’re playing Vayne in the top lane or in a more aggressive solo role, Flash + Ignite can also work for kill pressure

Best Runes For Vayne

The best runes for Vayne are:

Precision (Primary Tree)
• Keystone: Press the Attack – Amplifies your damage after three consecutive hits, perfect for Vayne’s quick auto attacks.
• Triumph – Heals on takedown and gives bonus gold, helping you survive close fights.
• Legend: Alacrity – Boosts attack speed, which scales perfectly with Vayne’s kit.
• Coup de Grace – Deal more damage to low-health enemies, helping secure kills faster.

Domination (Secondary Tree)
• Taste of Blood – Provides healing during trades and pokes.
• Treasure Hunter – Extra gold on first takedown against each enemy, helping you snowball faster.

Stat Shards
• Attack Speed
• Adaptive Force
• Armor or Magic Resist (depending on lane matchup)

This rune setup focuses on maximizing Vayne’s dueling power and scaling damage through constant trades and teamfights.

Best Build For Vayne

The best build for Vayne focuses on maximizing her attack speed, true damage, and mobility for both dueling and teamfighting. Start with Kraken Slayer as your Mythic for consistent damage output and true damage on-hit. Follow it with Berserker’s Greaves for attack speed. Next, go for Guinsoo’s Rageblade to convert crit into on-hit damage, synergizing perfectly with her W. Then build Blade of the Ruined King for lifesteal, percent-health damage, and chasing power. Phantom Dancer adds even more attack speed and mobility, and Guardian Angel gives you a second chance in late-game fights. For situational items, you can swap in Wit’s End for magic resist and on-hit damage, or Maw of Malmortius if you’re up against heavy burst AP champs.

Best Combos To Learn For Vayne

The best combos to learn for Vayne focus on maximizing her burst potential with quick tumbles and precise Condemn usage. A key trade combo is Auto → Q (Tumble) → Auto → E (Condemn), which lets you sneak in extra damage and possibly stun the enemy if you position correctly. In all-ins, especially post-6, go for R (Final Hour) → Q → Auto → Auto → E, using invisibility to reposition and catch enemies off guard. Another advanced trick is Q → E mid-animation, which buffers Condemn during Tumble for faster execution—great for catching enemies near walls. Mastering her wall stuns and spacing with Tumble is what separates good Vayne players from great ones.

Conclusion

Vayne is one of the most rewarding champions in League of Legends when mastered, offering insane outplay potential and high damage in the hands of skilled players. With the right build, runes, and mechanical combos, she can shred tanks, kite bruisers, and dominate late-game teamfights. Whether you’re diving into bot lane duels or dancing around threats in 1v3 scenarios, Vayne’s kit gives you the tools to carry hard. Practice your positioning, perfect your Tumble timings, and you’ll soon turn every fight into a highlight reel.