League of Legends Twitch Guide: Best Build, Runes, Combos

Twitch is a sneaky ADC in League of Legends known for his insane late-game damage and stealthy ambush plays. He can melt through entire teams with proper positioning and smart use of his abilities. In this guide, you’ll learn how to build Twitch for maximum impact, the best runes to boost his early and late-game power, and the most effective item paths to carry games. Whether you prefer to play him in bot lane or take over the jungle, this guide will give you the tools you need to make the Plague Rat a serious threat in every match.

Twitch Abilities Overview In League of Legends

Twitch’s kit is built around sneaky positioning, consistent poison damage, and massive teamfight potential when played right. His passive, Deadly Venom, applies true damage over time with each basic attack. Q – Ambush lets him enter stealth after a short delay, gaining attack speed and movement speed when exiting stealth—perfect for surprise engages. W – Venom Cask slows enemies in an area and applies stacks of his passive, making it easier to stick to targets. E – Contaminate deals burst damage based on the number of Deadly Venom stacks on enemies, often finishing off low-health targets. Finally, R – Spray and Pray is Twitch’s teamfight nuke, giving him bonus attack damage and huge attack range, letting him mow down entire teams when well-positioned.

How To Play Twitch In League of Legends

Best Summoner Spells For Twitch

The best summoner spells for Twitch are Flash and Heal. Flash gives Twitch a much-needed escape or reposition tool, especially since he’s squishy and vulnerable without mobility. Heal is great for survivability during trades or all-ins in bot lane, helping both him and his support. If you’re playing Twitch in the jungle, swap Heal for Smite to secure camps and objectives.

Best Runes For Twitch

The best runes for Twitch in most matchups are found in the Precision tree with Domination as a secondary. Here’s the optimal setup:

Primary – Precision:
• Keystone: Lethal Tempo – Boosts attack speed massively during fights, letting Twitch melt targets.
• Triumph – Restores health and gives bonus gold on takedowns.
• Legend: Alacrity – Grants more attack speed, which synergizes perfectly with his kit.
• Coup de Grace – Helps secure kills by increasing damage to low-health enemies.

Secondary – Domination:
• Taste of Blood – Adds sustain through poke trades in lane.
• Treasure Hunter – Gives bonus gold on unique takedowns, accelerating item spikes.

Stat Shards:
• Attack Speed
• Adaptive Force
• Armor or Magic Resist (based on enemy lane matchup)

This setup maximizes Twitch’s all-in potential, especially once he hits level 6 and activates Ambush + Spray and Pray for huge teamfight impact.

Best Build For Twitch

The best build for Twitch in League of Legends focuses on maximizing attack speed, critical strike, and on-hit effects to burst enemies quickly and stay dangerous in teamfights. Start with Kraken Slayer as your mythic for consistent damage, then build Berserker’s Greaves for attack speed. Follow up with Runaan’s Hurricane to spread your poison to multiple targets. After that, grab Infinity Edge to boost your crit damage, then Lord Dominik’s Regards to cut through armor. Finish with Guardian Angel or Bloodthirster depending on whether you need survivability or lifesteal. This full crit build gives Twitch insane late-game power, especially when he uses Ambush to get the jump on the enemy team.

Best Combos To Learn For Twitch

Here are the best combos to learn for Twitch to make the most out of his stealth, burst, and sustained damage:

1. Ambush + Spray and Pray (R) + Contaminate (E):
Start by activating Q (Ambush) to stealth and reposition. As you come out of stealth, activate R (Spray and Pray) for increased range and piercing shots. Auto-attack as many targets as possible to stack Deadly Venom, then press E (Contaminate) to finish them off with burst damage.

2. Ambush + Ignite + Full Auto + Contaminate:
For an all-in duel or assassination, activate Q, walk up undetected, drop Ignite, then auto multiple times and E right before the enemy escapes. This is deadly against squishier targets.

3. Ambush Flank + Runaan’s Hurricane + Spray and Pray:
This teamfight combo is game-changing. Use Q to flank the enemy backline, pop R with Runaan’s Hurricane equipped, and mow down multiple enemies from range. Clean up with E once your poison stacks are built.

4. Quick E Poke:
In lane, you can auto a few times then back off and use E for poke. It’s not a full combo, but great for chip damage and harassment.

Mastering these combos lets you catch enemies off-guard, win duels, and shred through teams before they can react.

Conclusion

Twitch is a high-risk, high-reward ADC who can carry entire games when played smart and aggressively. With the right build, optimal runes, and clean combos, he can melt through teams from stealth and dominate both solo lanes and teamfights. Whether you’re ambushing from the shadows or cleaning up with Contaminate, mastering Twitch’s mechanics and positioning is key to unlocking his full potential.