8 Best ADCs To Duo With Zoe Support In League of Legends

Zoe support might not be the most common pick in League of Legends, but in the right hands, she can be incredibly oppressive in lane. With her long-range poke, powerful crowd control from Sleepy Trouble Bubble, and unexpected burst potential, Zoe can set up kills and harass opponents constantly. When paired with the right ADC, Zoe’s support playstyle can become a nightmare for the enemy bot lane—creating pressure, forcing summoners, and opening up kill windows with ease. In this guide, we’ll break down the 8 best ADCs to duo with Zoe support, focusing on synergy, follow-up damage, and lane dominance.

#8: Aphelios

Aphelios pairs surprisingly well with Zoe support, especially when he’s holding strong poke or CC weapons like Gravitum or Severum. Zoe’s Sleepy Trouble Bubble sets up easy follow-up for Aphelios to root or burst down enemies with his rotating arsenal. Her long-range poke helps soften targets for Aphelios to finish off, and when he hits his power spikes, Zoe’s CC can lock enemies in place just long enough for him to melt them. While this duo may lack early all-in potential, their mid-game synergy can quickly turn fights in their favor with precise coordination and strong follow-up damage.

#7: Jinx

Jinx and Zoe make a great combo focused on picks and long-range punishment. Zoe’s Sleepy Trouble Bubble creates perfect opportunities for Jinx to land her Flame Chompers! and follow up with her rockets for big damage. If Zoe connects a bubble, Jinx can often secure a kill or at least a heavy chunk of damage with ease. Once Jinx gets excited with a reset, Zoe can help peel or keep the momentum going with her poke and stuns. This duo thrives in extended fights and chaotic skirmishes, where one pick can snowball into a teamfight win.

#6: Kai’Sa

Kai’Sa synergizes well with Zoe support thanks to her burst potential and ability to dive in after Zoe lands her crowd control. A well-placed Sleepy Trouble Bubble sets up the perfect opening for Kai’Sa to follow up with her full combo or even reposition aggressively with Killer Instinct. Zoe’s long-range poke also helps soften up targets, making it easier for Kai’Sa to secure kills and get ahead in lane. This duo is especially deadly once they both hit level 6, as Zoe’s poke forces the enemy to play back while Kai’Sa can instantly collapse on any sleeping or low-health target.

#5: Ashe

Ashe and Zoe form a strong utility-based lane that excels at punishing poor positioning and locking down targets. Zoe’s Sleepy Trouble Bubble gives Ashe an easy setup for Volley poke or a clean Enchanted Crystal Arrow follow-up, while Ashe’s slows make it easier for Zoe to land her skillshots. Together, they can control the lane with long-range poke, crowd control, and vision. This duo may not have explosive burst, but they make up for it with consistent pressure, great pick potential, and solid teamfight control as the game progresses.

#4: Varus

Varus is an excellent duo partner for Zoe support, especially in his lethality or poke-focused build. Zoe’s long-range bubble and burst combo create perfect windows for Varus to follow up with Piercing Arrow or Chain of Corruption, punishing enemies who get caught sleeping—literally. Both champions thrive on poking and whittling down opponents before committing to fights, making them a nightmare to lane against. Once level 6 hits, their combo potential skyrockets: one connected bubble into Varus ult can secure kills or force key summoner spells. It’s a high-pressure lane that rewards precision and aggressive positioning.

#3: Ezreal

Ezreal and Zoe make a strong, poke-heavy duo that keeps constant pressure on the enemy bot lane from a safe distance. Zoe’s bubbles and burst damage soften up targets, giving Ezreal easy opportunities to follow up with Mystic Shot and Trueshot Barrage. This pairing thrives in drawn-out trades and siege scenarios where both champions can chip away at the enemy without committing too hard. Ezreal’s mobility also allows him to reposition easily during chaotic fights, while Zoe’s crowd control creates windows for him to safely poke or clean up kills. Together, they control the lane through consistent harassment and strong pick potential.

#2: Caitlyn

Caitlyn and Zoe are a brutal lane duo when it comes to controlling space and punishing mistakes. Zoe’s Sleepy Trouble Bubble is the perfect setup for Caitlyn to place a Yordle Snap Trap underneath a sleeping target, guaranteeing a root and massive follow-up damage. Both champions excel at long-range poke, allowing them to harass relentlessly while staying safe behind minions. With strong zoning tools and lane dominance, this duo forces enemies to play defensively or risk getting chunked out early. Once they hit level 6, Zoe’s burst and Caitlyn’s Ace in the Hole can finish off any unlucky target caught napping.

#1: Jhin

Jhin is the best ADC to pair with Zoe support, thanks to their incredible synergy in both poke and pick potential. Zoe’s Sleepy Trouble Bubble sets up a perfect window for Jhin to land Deadly Flourish, instantly rooting the target and allowing for a follow-up combo. His long-range damage from Whisper and Curtain Call works perfectly with Zoe’s poke-heavy style, letting them whittle down opponents before a single bubble turns into a full-blown kill. In teamfights and laning alike, one mistake from the enemy often means a quick death when facing this deadly duo. Their combined range, burst, and CC make them an oppressive force in any game.

Conclusion

Zoe support may be off-meta, but when paired with the right ADC, she becomes a powerful playmaker capable of turning any bot lane into a constant threat. Whether you’re landing long-range bubbles to set up Jhin’s roots, poking enemies down for Ezreal, or creating trap combos with Caitlyn, Zoe’s utility and burst open up tons of kill opportunities. These 8 ADCs complement her strengths in different ways—some focus on poke and control, while others thrive off her pick potential to go all-in. With the right synergy and timing, Zoe support can turn the laning phase into a highlight reel and set the tone for the rest of the game.