10 Best ADCs To Duo With Dr. Mundo In League of Legends

Dr. Mundo support might sound unconventional, but in the right hands—and with the right ADC—it can be a surprisingly effective and tanky combo. Mundo brings incredible sustain, decent poke with his cleavers, and the ability to soak tons of damage during extended fights. While he doesn’t offer traditional crowd control, his durability and constant presence in lane allow aggressive or scaling ADCs to thrive without worrying about being zoned or bursted down. In this article, we’ll look at the 10 best ADCs to duo with Dr. Mundo support, focusing on pairings that bring out the best in his unkillable, in-your-face playstyle.

#10: Varus

Varus pairs well with Dr. Mundo support, especially when running a poke or lethality build. Mundo’s cleavers help slow and chip away at enemies, setting up easy shots for Varus to land Piercing Arrow from a safe distance. While Mundo tanks the front line and absorbs pressure, Varus can focus on poking or following up with Chain of Corruption when fights break out. This duo is great for maintaining lane control and wearing down opponents over time, with Mundo soaking the hits and Varus delivering the damage.

#9: Caitlyn

Caitlyn and Dr. Mundo make a strong lane duo built around range, pressure, and safety. While Mundo doesn’t provide hard engage, his cleavers and bulk help control the lane and zone enemies, giving Caitlyn the space she needs to poke and set up Yordle Snap Traps. Mundo can walk up and eat poke without fear, allowing Caitlyn to keep constant pressure on the enemy duo. His presence alone makes it hard for enemies to engage on her, and once she lands a trap or pokes them low, Mundo can chase them down with ease. It’s a solid combo for players who like to control lane and chip away safely.

#8: Ashe

Ashe pairs nicely with Dr. Mundo support thanks to her consistent slows and strong laning presence. Mundo’s cleavers help slow and zone enemies, while Ashe follows up with auto attacks and Volley to keep them locked down. This combo excels at kite-heavy trades where Ashe chips away from a distance and Mundo stands between her and any incoming threats. Once Ashe hits level 6, her Enchanted Crystal Arrow can initiate fights or catch enemies off-guard, giving Mundo a chance to run in and soak damage while Ashe finishes the job. It’s a lane built on control, safety, and reliable follow-up.

#7: Kalista

Kalista and Dr. Mundo make a surprisingly effective duo built around aggressive positioning and creative all-ins. Mundo’s natural tankiness lets him play front line and take poke, while Kalista freely weaves in damage with her mobility. The real strength comes from her ultimate, Fate’s Call, which lets her pull Mundo in and re-engage with a disruptive knock-up—making up for his lack of hard CC. Mundo can go in fearlessly, knowing Kalista can save him at any moment, and Kalista benefits from Mundo’s ability to take pressure off her in messy fights. It’s a chaotic, durable, and fun pairing for players who like nonstop action.

#6: Twitch

Twitch works surprisingly well with Dr. Mundo support, especially for players who like sneaky, late-game carry setups. Mundo’s main job in this duo is to absorb pressure, walk forward with cleavers, and draw attention away—giving Twitch the space he needs to farm safely and position for surprise engages. Once Twitch hits level 6, he can pop out of stealth and activate Spray and Pray while Mundo soaks up the front line and zones enemies. This duo doesn’t rely on flashy combos, but when Mundo protects Twitch long enough to deal damage, it becomes very hard for the enemy team to respond.

#5: Kog’Maw

Kog’Maw and Dr. Mundo make a classic protect-the-carry duo where Mundo’s job is to be the frontline wall while Kog’Maw melts everything behind him. Mundo’s cleavers slow enemies trying to dive, and his massive health pool lets him soak up tons of damage while Kog’Maw freely deals consistent DPS. This pairing shines in drawn-out fights, where Mundo’s regeneration and Kog’s long-range autos wear down the enemy team. It’s not flashy, but it’s brutally effective—especially in the late game when Kog’Maw becomes a monster with Mundo keeping him safe.

#4: Vayne

Vayne and Dr. Mundo are a strong duo built around patience, positioning, and late-game domination. Mundo’s job is to soak up damage and peel for Vayne while she shreds through frontline and squishy targets alike. His cleavers help slow enemies, giving Vayne more time to kite and land Condemn setups, while his massive durability keeps enemies off her back. Once Vayne hits her items, Mundo becomes a perfect meat shield, letting her play aggressively without fear. It’s a duo that might start slow, but with solid teamwork, can carry hard in the mid and late game.

#3: Samira

Samira and Dr. Mundo form a surprisingly effective duo built for chaotic, extended fights. While Mundo doesn’t have hard knockups, his constant slows and frontline pressure allow Samira to stack her passive quickly and dive in with confidence. Mundo’s ability to tank and stick to targets creates the space Samira needs to go all-in and unleash Inferno Trigger. Once Mundo hits level 6, he becomes nearly unkillable in skirmishes, buying even more time for Samira to clean up. It’s a brawler-style lane that rewards aggression, durability, and fearless engages.

#2: Jinx

Jinx and Dr. Mundo are a strong pairing built around safety, scaling, and teamfight dominance. Mundo’s tankiness and poke let Jinx farm comfortably in lane, and his presence alone makes it hard for enemies to engage on her. As fights break out, Mundo can soak up pressure and zone threats while Jinx kites and dishes out damage with rockets. Once she gets excited from a kill or assist, she can easily clean up fights while Mundo keeps enemies off her back. This duo shines in the mid to late game, where Jinx becomes a serious carry with Mundo holding the front line.

#1: Miss Fortune

Miss Fortune is the best ADC to pair with Dr. Mundo support thanks to her strong early damage, poke, and synergy in extended fights. Mundo’s cleavers help slow and zone enemies, creating perfect windows for MF to land Double Up or Make It Rain. In all-ins, Mundo tanks the frontline while MF positions safely to channel Bullet Time without interruption. Their laning is simple but effective—Mundo keeps pressure up and absorbs damage, while MF chips away and punishes oversteps. Once they hit level 6, one good engage can lead to a clean double kill. It’s a well-rounded duo that’s easy to play and hard to beat.

Conclusion

Dr. Mundo support might not bring traditional crowd control, but with the right ADC, he becomes a frontline nightmare that’s hard to deal with. His ability to soak damage, apply constant slows, and survive in long fights makes him a great partner for ADCs who need time and space to deal damage. Whether you’re scaling with Jinx or Kog’Maw, diving in with Samira or Kalista, or poking with Varus and Miss Fortune, Mundo sets the stage for his carry to shine. With smart positioning and teamwork, these duos can turn any bot lane into a long-lasting, high-pressure threat.