League of Legends: 7 Best Mid and Jungle Synergy

The synergy between Mid and Jungle in League of Legends can completely dominate the map and tilt the game in your favor. A coordinated duo in these roles can pressure lanes, secure objectives, and shut down the enemy team with relentless precision. In this article, we’ll highlight the 7 best Mid and Jungle pairings that excel in synergy, team fights, and ranked gameplay.

These combinations aren’t just based on raw statistics—they’re chosen for their ability to complement each other’s strengths, dominate the laning phase, and provide unparalleled impact throughout the game. If you’re looking to climb the ranks and win more games with your duo, these Mid and Jungle duos are guaranteed to make your opponents tremble. Let’s dive in!

#7: Viego and Lissandra

Viego and Lissandra are a match made in League of Legends synergy heaven. Viego thrives in chaotic skirmishes, picking off enemies and resetting fights with his passive, Sovereign’s Domination, while Lissandra excels at initiating and controlling enemies with her powerful crowd control abilities.

Lissandra’s Glacial Path and Ring of Frost create opportunities for Viego to dive in and secure kills with ease, especially when paired with her ultimate, Frozen Tomb, which locks down priority targets. This deadly combination of initiation and follow-up damage makes them perfect for shutting down squishy carries or neutralizing a fed opponent.

Beyond team fights, their synergy shines during ganks. Lissandra’s CC ensures that enemies have little chance to escape, allowing Viego to clean up and snowball early. Together, they’re a powerful duo for controlling the mid-lane and jungle, ensuring consistent pressure across the map.

#6: Nocturne and Twisted Fate

Nocturne and Twisted Fate create one of the most terrifying global duos in League of Legends. With their combined ability to impact the map from anywhere, they can take control of games through relentless ganks and coordinated dives.

Nocturne’s Paranoia ultimate blankets the map in darkness, cutting off enemy vision and creating confusion, while Twisted Fate’s Destiny allows him to teleport to any location to follow up. Together, they can single out isolated enemies, collapsing on them with almost no warning. The synergy between these two ultimates ensures there’s little room for the enemy to react.

This duo also excels at split-pushing and map control. Twisted Fate’s global pressure forces opponents to play cautiously, while Nocturne’s ability to dive from the shadows ensures that overextending enemies are punished. Their combined potential to create picks and secure objectives makes them a powerful force in both solo queue and organized play.

#5: Yasuo and Gragas

Yasuo and Gragas form a dynamic duo that thrives on engaging and disrupting team fights with explosive synergy. Gragas’s Body Slam and Explosive Cask abilities create the perfect setup for Yasuo’s Last Breath, ensuring devastating combos that can turn the tide of any skirmish.

Gragas’s Explosive Cask is particularly effective for knocking up multiple enemies, giving Yasuo the opportunity to chain his ultimate and unleash massive area-of-effect damage. This combo excels in team fights, especially when executed in crowded spaces where enemy champions have limited mobility.

In the laning phase, Gragas can gank mid-lane effectively, using his CC and sustain to keep Yasuo safe and help him secure kills. Meanwhile, Yasuo’s mobility and Wind Wall provide cover for Gragas in skirmishes, making them a versatile and mutually beneficial pair.

This pairing is especially potent in ranked play, where coordinated aggression can snowball games quickly. Together, Yasuo and Gragas capitalize on their shared strengths to dominate team fights and secure leads, making them a favorite duo for players who love flashy plays and high-impact combos.

#4: Evelynn and Anivia

Evelynn and Anivia create an incredible synergy rooted in their ability to control and disrupt the battlefield with their crowd control and burst damage. This pairing thrives on patience and precision, delivering devastating results when their abilities are combined effectively.

Evelynn’s stealth and unpredictable presence allow her to flank and pick off vulnerable targets with her Charm from Allure (W), setting up a perfect opportunity for Anivia to land her Flash Frost (Q) and Frostbite (E) combo. The burst damage from this chain of abilities can easily delete squishy targets before a fight even begins.

Anivia’s Glacial Storm (R) and Crystallize (W) provide exceptional zoning and control during team fights, which pairs perfectly with Evelynn’s tendency to dive into the backline. The ice wall can trap enemies within Evelynn’s ultimate range, ensuring her Last Caress (R) deals maximum damage. Together, they can execute coordinated ganks and secure kills in mid-lane, snowballing the game in their favor.

This duo excels in both pick-oriented and teamfight scenarios, making them a strong choice in ranked games. Evelynn’s stealth and Anivia’s area denial make it nearly impossible for enemies to regain control once this pair establishes dominance.

#3: Bel’Veth and Malzahar

Bel’Veth and Malzahar are an exceptional duo that thrives on their shared ability to lock down targets and secure objectives efficiently. Their synergy is built on crowd control, sustained damage, and incredible map control.

Malzahar’s Call of the Void (Q) and Nether Grasp (R) provide powerful crowd control tools, ensuring that Bel’Veth has ample time to deal massive damage. His Malefic Visions (E) combined with Voidling spawns offers excellent wave clear and pushes enemies into unfavorable positions, allowing Bel’Veth to capitalize with her relentless melee attacks. Additionally, Malzahar’s Nether Grasp (R) roots enemies in place, creating a perfect window for Bel’Veth to shred them with her empowered autos and Royal Maelstrom (E).

Bel’Veth’s ultimate, Endless Banquet (R), gains immense value from Malzahar’s ability to secure kills or assists with his reliable lockdown. This allows Bel’Veth to transform into her true form, snowballing her impact in fights and objectives like Baron or Dragon.

Their synergy extends beyond fights; both champions excel at controlling neutral objectives. Malzahar’s Voidlings and Bel’Veth’s empowered form provide exceptional DPS against neutral monsters, enabling them to secure these game-changing buffs efficiently.

This duo is especially effective in ranked games, where coordinated plays can tilt the game in their favor. With Malzahar’s lane dominance and Bel’Veth’s scaling power, they’re a nightmare for teams that can’t handle their methodical playstyle.

#2: Jarvan IV and Orianna

Jarvan IV and Orianna form one of the most iconic and devastating Mid-Jungle synergies in League of Legends. Their ability to seamlessly chain their abilities together creates game-changing team fight potential and can turn the tide of any match.

Jarvan IV’s Cataclysm (R) is the perfect setup for Orianna’s Command: Shockwave (R). When Jarvan dives into the enemy team, locking them inside his arena, Orianna can place her ball directly on him and unleash a devastating Shockwave to hit multiple targets simultaneously. This deadly combination can wipe out squishy carries and disrupt the enemy’s formation, leaving them vulnerable for follow-up damage.

Beyond their ultimate synergy, Jarvan’s Dragon Strike (Q) and Demacian Standard (E) combo provide excellent early-game gank potential, enabling Orianna to play aggressively in the mid lane. Meanwhile, Orianna’s Command: Protect (E) can shield Jarvan, giving him additional durability during dives and skirmishes.

In team fights, Jarvan serves as the primary engager, while Orianna provides sustained damage and utility. Together, they excel at controlling objectives like Baron and Dragon, as their AoE damage and crowd control make them extremely dangerous in chokepoints.

This duo is especially potent in ranked games, where coordination can lead to dominating team fights and rapid snowballing. With Jarvan’s early pressure and Orianna’s scaling potential, they’re a nightmare for teams lacking proper disengage tools.

#1: Lee Sin and LeBlanc

Lee Sin and LeBlanc form one of the most electrifying and high-skill Mid-Jungle duos in League of Legends, offering unparalleled mobility, damage, and outplay potential. Their synergy thrives on early-game aggression, making them a deadly combination that can dominate the map when executed properly.

Lee Sin’s early-game presence is unmatched, with his Sonic Wave (Q) and Resonating Strike (Q2) combo allowing him to close gaps and secure kills. Combined with LeBlanc’s burst potential through Distortion (W) and Sigil of Malice (Q), they can quickly delete squishy targets. LeBlanc’s chain crowd control from Ethereal Chains (E) ensures that Lee Sin can land his skill shots with precision, while her mobility allows her to follow up on his aggressive plays seamlessly.

This duo excels at invading the enemy jungle, creating chaos, and snowballing the game by targeting vulnerable laners or junglers. With Lee Sin’s ability to secure objectives like Dragon or Rift Herald early on, LeBlanc can use her wave-clear and roam potential to support these efforts and punish overextending enemies.

In team fights, the duo relies on surgical precision and coordinated targeting. Lee Sin’s Dragon’s Rage (R) can be used to kick key targets into LeBlanc’s range, allowing her to burst them down instantly. Their mobility and ability to quickly disengage make them nearly impossible to catch, adding immense pressure on the enemy team.

Lee Sin and LeBlanc require strong mechanical skills and coordination, but in the hands of capable players, they can dominate solo queue games and snowball out of control. Their early-game power and ability to create opportunities for their team make them the ultimate Mid-Jungle synergy for players looking to climb the ranked ladder.

Conclusion

The synergy between Mid and Jungle champions can make or break a game in League of Legends, especially in ranked play where coordination is key. The combinations we’ve highlighted—ranging from the early-game dominance of Lee Sin and LeBlanc to the map-wide control of Nocturne and Twisted Fate—offer diverse playstyles and strategic advantages. Whether you’re looking to dominate team fights, execute ganks with precision, or scale into the late game, these duos provide the tools to outsmart and overpower your opponents.

By mastering the strengths and strategies of these champion pairings, you and your duo partner can turn the tides of any match, climbing the ranks together and showcasing your teamwork. Remember, communication and synergy are just as vital as mechanics, so work closely with your Jungle or Mid partner to make the most of these deadly combos. Now, it’s time to jump into the Rift and start winning games with the ultimate Mid and Jungle pairings!