Best Neurode Farming Locations In Warframe

Neurodes are one of Warframe’s more elusive crafting materials, often needed for Warframe blueprints, weapons, and various upgrades. These rare Infested-based resources can drop across multiple planets, but some nodes are significantly more efficient than others—especially if you’re trying to farm quickly. If you’re tired of wasting time chasing inconsistent drops, this guide highlights the best spots to farm Neurodes fast and consistently. Whether you’re a new player or a veteran looking to stock up, here are the top locations that make Neurode farming actually worth your time.

#10: Zabala (Eris)

Zabala is a high-level Survival mission on Eris that’s perfect for late-game players looking to farm Neurodes efficiently. As a Dark Sector mission, it offers a solid +30% resource drop rate, plus bonus Affinity for Pistols—great for leveling gear while farming. Since Eris is heavily Infested territory, enemies here drop Neurodes more frequently, especially the longer you stay. On top of that, Zabala drops a variety of Neo Relics like A13, G8, and W2, making it an ideal farming spot for both crafting materials and Prime gear components. It’s a challenging node, so bring a strong Warframe and coordinate with a squad to maximize your rewards.

#9: Plains of Eidolon

If you’re looking for a more relaxed way to farm Neurodes without grinding through traditional missions, the Plains of Eidolon offers a great alternative. As Warframe’s first open-world zone, it lets players freely explore, fight roaming enemies, and uncover hidden loot spots. Neurodes can be found here by destroying Neuroptic Masses, which are scattered across the landscape. To make the process easier, equip mods like Loot Detector, Thief’s Wit, or Animal Instinct to highlight these resource nodes on your minimap. While it’s not the fastest method, it’s a solid passive farming option for players who enjoy exploring or multitasking while gathering resources.

#8: Terrorem (Deimos)

Unlocked early on after reaching Mars, Terrorem is a Survival mission on Deimos that’s surprisingly efficient for farming Neurodes. Thanks to its Orokin Derelict tileset, Infested enemies are everywhere—giving you steady chances at Neurode drops the longer you survive. While it may not be as fast-paced as some endgame nodes, Terrorem shines as a mid-game farming spot for players transitioning into tougher content. You’ll also get access to Lith relics like A6, M9, and W4, making it a good choice for relic farming alongside Neurodes. Its eerie, derelict setting and Infested atmosphere also serve up a creepy reminder of what went wrong with the Orokin’s twisted experiments.

#7: Plato (Lua)

Plato, located on Lua, is a high-yield Survival mission that offers a strong chance to farm Neurodes, though it’s not for the faint of heart. With enemies ranging from level 25 to 40, this mission ramps up in difficulty fast, so it’s best tackled with a well-equipped loadout or a coordinated squad. Bringing a sniper rifle or long-range weapon can help you stay safe while picking off enemies from a distance.

Sentients frequently appear during the mission and are a reliable source of Neurodes. Beyond that, Plato is also a great source of valuable resources like Plastids, Rubedo, Polymer Bundles, and Argon Crystals. There’s even a chance to grab the Octavia Systems Blueprint, making Plato a rewarding node for players pushing through Lua.

#6: Mutalist Alad V (Assassination Mission)

Mutalist Alad V is one of Warframe’s more iconic recurring villains, and his Infested form on Eris offers a solid opportunity for Neurode farming. After completing the “Patient Zero” quest, you’ll unlock the Mutalist Alad V Assassinate Key Blueprint, which lets you craft the key needed to access his boss fight. While the mission isn’t overly difficult, it’s still best tackled with a well-geared Warframe and a full squad to speed up kills and improve your chances at Neurode drops.

Besides farming for resources, defeating Mutalist Alad V also gives you a shot at the Mesa Chassis Blueprint, making this mission worth doing even if you’re hunting for more than just crafting materials. It’s not the fastest method, but it’s a reliable boss farm with good loot potential—especially for those looking to build Mesa.

#5: Magnacidium (Deimos)

Located on the Infested moon of Deimos, Magnacidium is an Assassination mission where players face off against Lephantis, a grotesque three-headed boss that fuses elements of Grineer, Corpus, and Ancient Infested enemies. Each head comes with its own deadly attacks—poison clouds, sweeping scythe slashes, and explosive spore projectiles—making this a fight that demands mobility, awareness, and a strong loadout.

While challenging, this mission is a great source of Neurodes, as each head has a chance to drop them individually. You’ll also get a chance at Orokin Cells during the encounter. Additionally, Magnacidium is the only way to earn all three Nekros Warframe blueprints (Chassis, Systems, and Neuroptics), each with a 33.33% drop rate, making this a top-tier farm for both resources and Warframe parts.

#4: Mantle (Earth)

Mantle is one of the earliest missions you’ll encounter in Warframe, located on Earth, and it’s surprisingly efficient for early-game Neurode farming. This Capture mission has a simple objective: hunt down and capture a target before they escape. Once that’s done, the mission shifts into an Exterminate mode, giving you the freedom to roam the map, clear enemies, and search for loot—particularly Neurodes.

The map layout is fairly small, making it ideal for players looking to farm quickly and reset the mission for repeated runs. Equip mods like Loot Detector or Thief’s Wit to highlight Neuroptic Masses, which have a chance to drop Neurodes when destroyed. Whether you’re just starting out or returning to stock up on rare materials, Mantle is a convenient and time-efficient spot to grind.

#3: Tycho (Lua)

Tycho is a Survival mission located on Lua, and it’s one of the better places to farm Neurodes—especially for late-game players. In this mission, you’ll be fighting off waves of increasingly tough enemies while managing your dwindling life support. Every few minutes, Lotus will drop life support capsules, and enemies may drop health orbs to keep you going. The longer you survive, the better the rewards—including a solid chance at Neurodes.

Alongside Neurodes, you can collect materials like Ferrite, Rubedo, and Detonite Ampules, as well as useful mods such as Serration, Flow, Split Chamber, and Hornet Strike. Tycho also drops Neo Relics like A13, L4, and Z11, making it a rewarding run for both resources and gear. With enemy levels starting at 25–30, it’s best to bring a well-equipped Warframe and strong weapons—especially if you’re planning to push longer runs. Shotguns work well here for close-range crowd control, and the Infested enemies make status-heavy or AoE builds shine.

#2: Mariana (Earth)

Mariana is one of the first Exterminate missions players unlock on Earth, and while it’s simple in design, it’s surprisingly effective for early-game Neurode farming. The mission is fast, straightforward, and features low-level enemies (Level 1–3), allowing you to tear through waves without much resistance. Since it’s an Exterminate node, all you need to do is clear out every enemy on the map, with a decent chance of finding Neurodes along the way.

What makes Mariana such a solid pick is its compact map layout, making it easy to sweep the entire area quickly and restart the mission in minutes. It’s also a great spot to level low-rank gear while farming resources like Ferrite, Rubedo, and Detonite Ampules. For new players and veterans alike, Mariana remains one of the most efficient early-game farming loops Warframe has to offer.

#1: Tikal (Earth)

Tikal stands out as one of the absolute best spots for Neurode farming in Warframe, especially for newer players. Located on Earth, this Dark Sector Excavation mission offers a solid +15% resource drop chance, along with Affinity bonuses—including a +12% general Affinity boost and an extra +8% for melee weapons, making it great for ranking gear while farming. You’ll also pick up regional materials like Ferrite, Rubedo, and Detonite Ampules along the way.

Because it’s an Excavation mission, you’ll be constantly on the move, fighting off waves of enemies while defending drills. Neurodes can drop from enemies or be found by breaking Neuroptic Masses scattered around the Grineer Forest tileset. And since Tikal is available relatively early after completing “Saya’s Vigil”, it’s perfect for testing new builds or leveling unranked gear without much risk. Fast, efficient, and beginner-friendly—Tikal remains the top pick for consistent Neurode farming.

Conclusion

Whether you’re a new Tenno just starting out or a veteran stocking up for crafting endgame gear, farming Neurodes is essential—and knowing where to look can save you a ton of time. From early-game missions like Mariana and Tikal to more advanced farming spots like Tycho and Zabala, there’s a perfect node for every progression level. Equip loot-enhancing mods, bring the right Warframe, and pick the mission that fits your pace. With the right strategy, you’ll have a healthy Neurode stockpile ready for whatever blueprints you’re chasing next.