Old School RuneScape: 15 Best Potions

Potions are a vital part of success in Old School RuneScape, offering boosts and support in nearly every aspect of gameplay. Whether you’re restoring prayer points, curing poison, or enhancing your combat stats, the right potion can make a world of difference in your efficiency and survival.

With so many potions to choose from, it can be overwhelming to figure out which ones are truly worth keeping stocked in your inventory or bank. The right potion can save you time, money, and stress, helping you tackle everything from tough bosses to demanding Slayer tasks with ease.

In this article, we’ll explore the 15 best potions in OSRS, breaking down their benefits and why they’re essential for adventurers of all levels. Get ready to boost your gameplay with these must-have potions!

#15: Weapon Poison++

Weapon Poison++ is one of the strongest poisons available in Old School RuneScape, and it’s an essential potion for players who want to deal extra damage over time in both PvM and PvP scenarios. When applied to weapons such as daggers, spears, or darts, it adds a poison effect that can deal increasing damage over several ticks.

This potion is particularly useful for PvP fights or encounters against enemies that can’t heal quickly, as the poison can slowly chip away at their health. It’s also great for tools used in Poison Dynamite hunting or dealing with certain high-health Slayer monsters.

Players can craft Weapon Poison++ with 82 Herblore, using cactus spine, poison ivy berries, and a coconut milk, making it accessible for high-level Herblorists.

While it may not be a combat staple for every situation, Weapon Poison++ is invaluable for players who want to maximize their DPS in specific encounters or dominate in PvP with strategic poison application.

#14: Hunter Potion

The Hunter Potion is a niche but highly useful potion for players training their Hunter skill in Old School RuneScape. When consumed, this potion temporarily boosts your Hunter level by +3, allowing access to traps, creatures, or activities that require a level just out of reach.

This potion is particularly helpful for players trying to place extra traps during training or complete tasks that require a slightly higher Hunter level without grinding additional levels. It’s especially effective for hunting Chinchompas, Black Salamanders, or creatures like Herbiboar, where a higher level can improve efficiency and success rates.

To make a Hunter Potion, you’ll need 53 Herblore, a Fellstalk Herb, and an Avantoe potion (unf). It’s easy to craft and widely accessible for mid-level players.

While not essential for all players, the Hunter Potion is a great utility for those focusing on their Hunter skill, allowing more flexibility and faster progression during training sessions.

#13: Divine Battlemage Potion

The Divine Battlemage Potion is a hybrid potion in Old School RuneScape that boosts both Magic and Defense levels, making it an excellent choice for players who want to enhance their magic combat capabilities while maintaining durability. It raises your Magic level by +4–13 (depending on your level) and your Defense level by +3–12.

What makes this potion unique is its divine effect, which prevents stat drain for 5 minutes, allowing you to maintain your boosted levels throughout prolonged combat encounters. This is particularly useful in PvM activities like Slayer, bossing, or even Chambers of Xeric, where sustained performance is key.

To create a Divine Battlemage Potion, you need 78 Herblore, along with Battlemage Potion (unf) and a Crystal Dust made from crushing Crystal Shards. While its ingredients can be pricey, the potion’s benefits justify its cost in challenging scenarios.

For mages looking to maximize their offensive and defensive capabilities simultaneously, the Divine Battlemage Potion is an invaluable tool for long-lasting performance in tough fights.

#12: Agility Potion

The Agility Potion is a practical option for players looking to temporarily boost their Agility level by +3, unlocking shortcuts or activities that would otherwise be inaccessible. While it’s not as widely used as other potions, it can save players time and effort in specific scenarios.

This potion is particularly helpful for passing agility obstacles during quests, accessing areas with level requirements, or boosting success rates at courses like the Wilderness Agility Course. It’s also useful for reaching higher shortcuts during Slayer tasks or skilling in places like the Taverley Dungeon.

To make an Agility Potion, players need 34 Herblore, a Toadflax, and a Toad’s Legs. It’s an easy potion to craft for mid-level Herblorists and remains affordable for most players.

While not essential for everyday use, the Agility Potion is a convenient and situationally useful item for players who occasionally need an extra boost to their Agility level to save time or gain access to restricted areas.

#11: Extended Super Antifire

The Extended Super Antifire Potion is a must-have for any player tackling dragons in Old School RuneScape, providing complete immunity to dragonfire attacks for an extended duration of 12 minutes. This makes it an invaluable tool for PvM activities such as Slayer tasks, Vorkath, or general dragon hunting.

Unlike regular Antifire Potions, the super variant completely negates dragonfire damage, even without an Anti-Dragon Shield, allowing more flexibility in gear setups. The extended version ensures players can focus on fighting without the need to frequently re-dose, making it particularly useful for longer trips or bossing encounters.

To create an Extended Super Antifire, players need 92 Herblore, a Super Antifire Potion (unf), and Lava Scale Shards. While the potion requires a high Herblore level to make, it’s also available on the Grand Exchange for convenience.

For adventurers who regularly face dragons or are tackling endgame bosses like Vorkath, the Extended Super Antifire Potion is a game-changer, offering unparalleled protection and convenience.

#10: Super Strength Potion

The Super Strength Potion is a staple for melee-focused players in Old School RuneScape, providing a significant boost to your Strength level by +5–19, depending on your current level. This increase enhances your max hit, making it invaluable for PvM, PvP, and general melee training.

Requiring 55 Herblore to craft, the potion is made by combining a Kwuarm with Limpwurt Root in a vial of water. It’s widely available and affordable, making it a go-to item for players at all stages of progression.

The Super Strength Potion is commonly used during Slayer tasks, bossing, and even in Chambers of Xeric, where maximizing DPS is critical for efficiency. It’s also an essential item in PvP encounters, where every hit counts.

For melee adventurers looking to improve their damage output without breaking the bank, the Super Strength Potion is a reliable and cost-effective solution that ensures consistent performance in combat.

#9: Guthix Rest Tea

The Guthix Rest Tea is a unique and versatile potion in Old School RuneScape that serves as a combination of minor healing, poison curing, and stamina restoration. It’s especially favored for its ability to cure poison and venom, making it a handy item for various PvM and skilling activities.

Each sip of Guthix Rest Tea restores 5 hitpoints, reduces poison damage by one level, and grants a small run energy boost, making it a popular choice for bossing, questing, or skilling in hazardous areas like the Wilderness or TzHaar Fight Cave. It’s also useful during Slayer tasks where poison might be a frequent issue.

To make this tea, players need 20 Cooking and must brew it using Guam Leaves, Harralander, and a cup of hot water. It’s an affordable and easily crafted item, which adds to its appeal for players across all levels.

For adventurers looking for a practical and multi-purpose item, the Guthix Rest Tea is a great addition to any inventory, providing situational utility that can save you in critical moments.

#8: Prayer Potion

The Prayer Potion is one of the most widely used potions in Old School RuneScape, essential for restoring prayer points during PvM, Slayer tasks, and PvP encounters. With each dose restoring 7 + 25% of your total prayer points, it’s a crucial item for players relying on protection or offensive prayers to maximize their effectiveness in combat.

Crafting a Prayer Potion requires 38 Herblore, combining a Ranarr Weed with Snape Grass in a vial of water. Its ingredients are relatively easy to obtain, making it a readily accessible potion for players at various stages of the game.

The Prayer Potion is indispensable for activities such as boss fights (e.g., God Wars Dungeon or Barrows), Slayer tasks, and Chambers of Xeric, where maintaining prayer is critical for survival and efficiency. It’s also frequently used in PvP to sustain protection prayers or offensive boosts like Piety and Rigour.

Affordable, reliable, and universally useful, the Prayer Potion remains a staple for adventurers tackling OSRS’s most demanding content. No inventory is complete without it!

#7: Anti-venom+

The Anti-venom+ is the ultimate potion for curing and preventing both venom and poison in Old School RuneScape. When consumed, it instantly cures venom and poison while granting three minutes of immunity against being re-venomed or re-poisoned, making it essential for encounters where these mechanics are prevalent.

This potion is particularly useful when facing venomous enemies like Zulrah, Vorkath, or enemies in the Wilderness, where venom can quickly deplete your health if not managed. The extended duration of protection ensures you can focus on combat without constantly re-dosing.

Crafting Anti-venom+ requires 94 Herblore and involves combining Anti-venom with Torstol, making it a high-level but invaluable potion for endgame players. It can also be purchased on the Grand Exchange for convenience.

For players tackling venom-heavy bosses or PvP situations, the Anti-venom+ is a must-have, offering both immediate relief and lasting immunity, ensuring a smoother and safer combat experience.

#6: Super Restore Potion

The Super Restore Potion is a highly versatile and widely used potion in Old School RuneScape, capable of restoring prayer points and all drained stats (excluding Hitpoints). This makes it a staple for high-level PvM, Slayer, and questing activities where managing prayer and combat stats is critical.

Each dose of a Super Restore Potion restores 8 + 30% of your total prayer points while also fully restoring reduced stats such as Attack, Strength, Defense, Magic, and Ranged. It’s particularly useful during boss fights where enemies drain stats, such as the Great Olm in the Chambers of Xeric or Verzik Vitur in the Theatre of Blood.

Crafting this potion requires 63 Herblore, using Snapdragon and Red Spider’s Eggs. While slightly more expensive than standard Prayer Potions, its ability to restore drained stats makes it invaluable in situations where stat reduction is frequent.

For adventurers tackling challenging content or prolonged fights, the Super Restore Potion is a must-have for keeping prayer points up and ensuring combat effectiveness throughout the encounter.

#5: Divine Bastion Potion

The Divine Bastion Potion is a game-changing choice for rangers in Old School RuneScape, combining a Ranging Potion and a Super Defence Potion into one. This powerful hybrid potion boosts both Ranged attack and defense levels significantly, making it perfect for high-level PvM encounters and PvP scenarios.

What sets the Divine Bastion Potion apart is its divine effect, which prevents stat drain for five minutes after consumption. This means you can maintain your boosted stats throughout extended fights, ensuring consistent performance without needing to re-dose. The potion raises Ranged by +4–13 (based on level) and Defense by +5–20, depending on your levels.

To craft a Divine Bastion Potion, players need 86 Herblore and must combine a Bastion Potion (unf) with Crystal Dust, obtained by grinding Crystal Shards. While crafting requires a high Herblore level, the potion is also available on the Grand Exchange for convenience.

Ideal for boss fights like Zulrah, Vorkath, and Chambers of Xeric, or for PvP encounters where survival and DPS matter most, the Divine Bastion Potion is a must-have for rangers aiming to optimize their performance.

#4: Sanfew Serum

The Sanfew Serum is one of the most versatile potions in Old School RuneScape, offering a unique combination of effects. It restores prayer points, cures poison, and removes disease, making it an essential tool for players facing a variety of challenges.

Each dose of the Sanfew Serum restores 7 + 25% of your total prayer points, similar to a Prayer Potion, while also acting as an Antipoison and Relicym’s Balm in one. This makes it particularly useful for PvM encounters where players face multiple status effects, such as Zulrah or Slayer tasks with venomous or poisonous monsters.

To craft a Sanfew Serum, you’ll need 65 Herblore, along with a Super Restore Potion, Unicorn Horn Dust, Snake Weed, and Nail Beast Nails. While it’s not the cheapest potion to make or buy, its combination of benefits makes it worth the cost for many players.

For adventurers who value efficiency and utility in challenging content, the Sanfew Serum is a reliable and multi-purpose solution that can save inventory space while keeping you prepared for anything.

#3: Stamina Potion

The Stamina Potion is a must-have for players in Old School RuneScape who need to keep their run energy high during long treks, skilling, or combat. It restores 20% run energy per dose and provides a two-minute buff that reduces run energy drain by 70%, making it invaluable for activities that require constant movement.

Stamina Potions are essential for a variety of tasks, including Agility training, Slayer tasks, bossing, and even general exploration across Gielinor. Whether you’re running laps at the Ardougne Agility Course, chasing Herbiboars, or dodging dangerous enemies in the Wilderness, this potion ensures you stay mobile and efficient.

Crafting a Stamina Potion requires 77 Herblore, combining Amylase Crystals with Super Energy Potions. While the crafting cost can add up, these potions are widely available on the Grand Exchange, making them accessible to all players.

For adventurers who prioritize speed and efficiency, the Stamina Potion is an essential tool that saves time and keeps you running strong through any challenge.

#2: Divine Super Combat Potion

The Divine Super Combat Potion is a powerful hybrid potion in Old School RuneScape that boosts all three melee combat stats: Attack, Strength, and Defence. It offers the same stat boosts as a standard Super Combat Potion—+5–19 in Attack and Strength and +5–20 in Defence, depending on your current levels—but with one crucial advantage: the divine effect.

This divine effect prevents your boosted stats from draining for five minutes, making it perfect for long-duration PvM encounters, such as God Wars Dungeon, Slayer tasks, or Theatre of Blood, where sustained performance is key. The potion eliminates the need for frequent re-dosing, allowing you to focus on the fight.

Crafting this potion requires 97 Herblore and involves combining a Super Combat Potion (unf) with Crystal Dust, created by grinding Crystal Shards. While the potion is expensive to make or buy, its efficiency makes it a worthy investment for high-level players tackling endgame content.

For melee-focused adventurers aiming to maximize damage output and defense without interruptions, the Divine Super Combat Potion is a game-changing addition to your inventory.

#1: Saradomin Brew

The Saradomin Brew is widely regarded as one of the most essential and versatile potions in Old School RuneScape, offering unmatched healing and defensive benefits. Each dose restores 15% of your Hitpoints and boosts your Defense by 20% of your base level, making it invaluable for surviving tough PvM encounters and clutch situations in PvP.

The Saradomin Brew is a staple in boss fights such as Zulrah, Vorkath, Tombs of Amascut, and Theatre of Blood, where high damage and extended encounters demand both sustained healing and increased defense. However, it does come with a drawback: each dose reduces your Attack, Strength, Magic, and Ranged stats by 10%. This tradeoff is often mitigated by pairing it with Super Restores or Overloads to maintain offensive capabilities.

Crafting Saradomin Brews requires 81 Herblore, combining Toadflax and Crushed Bird Nests. While it’s not the cheapest potion to make, its effectiveness justifies the cost for endgame content and high-stakes situations.

For adventurers seeking the best potion to ensure survivability, the Saradomin Brew is an absolute must-have. Its healing power and defensive boosts make it a reliable companion for RuneScape’s toughest challenges.

Conclusion

Potions in Old School RuneScape are essential tools that enhance every aspect of gameplay, from combat and skilling to survivability and efficiency. Whether you’re tackling tough bosses, completing Slayer tasks, or simply exploring Gielinor, the right potion can make a world of difference.

From the versatile Saradomin Brew to specialized options like the Divine Super Combat Potion or Stamina Potion, each potion on this list offers unique benefits tailored to specific challenges. Knowing when and how to use these potions can save you time, money, and stress, ensuring smoother adventures and greater success in both PvM and PvP.

So stock up wisely, craft strategically, and let these potions boost your performance as you conquer OSRS’s toughest challenges and reach your goals!