League of Legends Seraphine Guide: Best Build, Runes, Items, Combos

Seraphine is a powerful enchanter-mage in League of Legends who shines in both the bot lane and mid lane thanks to her long-range poke, crowd control, and game-changing utility. With her ability to heal allies, set up fights, and deal consistent magic damage from a safe distance, Seraphine offers a flexible and impactful playstyle. Whether you’re supporting your team or dishing out damage, using the right build, runes, and item setup is key to unlocking her full potential and making a difference in every fight.

Seraphine Abilities Overview In League of Legends

Here’s a full overview of Seraphine’s abilities in League of Legends:

Passive – Stage Presence: Every third basic ability cast echoes, casting it a second time. Additionally, casting abilities near allies grants Notes, which increase her next auto-attack range and deal bonus magic damage based on the number of Notes.

Q – High Note: Seraphine fires a soundwave that deals magic damage, increased based on the enemy’s missing health. When echoed, it deals the damage a second time.

W – Surround Sound: Seraphine shields herself and nearby allies, then heals them if she’s already shielded. Echoed casts apply the effect twice, potentially doubling healing and shielding if timed right.

E – Beat Drop: She sends out a soundwave in a line that damages and slows enemies. If enemies are already slowed, they get rooted; if already rooted, they get stunned instead. Echoing it can chain CC effectively.

R – Encore: Seraphine’s ultimate sends a long-range charm in a line that extends if it hits a champion or ally. It charms, damages, and grants max Notes for each enemy hit, making it perfect for turning fights or catching multiple enemies.

Mastering her timing and positioning with these abilities is key to dominating in teamfights and supporting your squad.

How To Play Seraphine In League of Legends

Best Summoner Spells For Seraphine

The best summoner spells for Seraphine are usually Flash and Heal when played as a bot lane carry, or Flash and Ignite/Exhaust when played as a support. Flash is essential for repositioning and escaping, while Heal provides sustain for both you and your ADC. Ignite adds kill pressure in lane, and Exhaust helps shut down bursty enemies. Choose based on your role and lane matchup.

Best Runes For Seraphine

The best build for Seraphine in League of Legends focuses on maximizing her poke, utility, and healing. Whether you play her as a support or mid laner, here’s a strong standard build that works well in most games:

Starting Items:
• Support: Spellthief’s Edge + Health Potions
• Mid Lane: Doran’s Ring + Health Potion

Core Items:
• Moonstone Renewer – Provides great healing and synergy with her AoE abilities
• Staff of Flowing Water – Boosts AP and movement speed for allies
• Ardent Censer – Grants bonus attack speed and healing on shields
• Optional alternative: Liandry’s Torment (if you’re playing full AP for more damage in mid lane)

Situational/Boots:
• Ionian Boots of Lucidity – Lower cooldowns for abilities and summoners
• Redemption – Adds AoE healing and map-wide teamfight presence
• Mikael’s Blessing – If the enemy has heavy CC
• Rylai’s Crystal Scepter – Extra health and slows enemies for better utility
• Zhonya’s Hourglass – If you’re being focused or need survivability

This build keeps Seraphine relevant through poke, healing, and utility while still letting her scale with AP and stay safe in fights.

Best Combos To Learn For Seraphine

Here are the best Seraphine combos to learn that will help you poke, peel, and set up big plays in fights:

1. Basic Poke Combo (Lane Harass):
E → Q → Auto
Use E (Beat Drop) to slow or root your target, then follow up with Q (High Note) for bonus damage. If your passive is ready, your Q or E will echo for extra poke. Always auto after your spells to weave in passive damage.

2. Root Combo:
E → Passive-Enhanced E → Q
If your passive is charged, double cast E to root enemies immediately, then land a full-power Q on them while they’re stuck.

3. All-In Teamfight Combo:
R → E → Q → W
Start with R (Encore) from a distance to charm multiple enemies. Follow with E to root them (R extends E’s crowd control), then drop Q for burst and use W (Surround Sound) to shield and heal your team.

4. Self-Peel Combo:
W → E → Q
If you’re being dived, use W for a shield and potential heal, then slow or root the enemy with E and push them back with Q. This keeps you alive and helps your team turn the fight.

Mastering these combos will let you consistently set up picks, provide utility, and control teamfights with ease.

Conclusion

Seraphine is a powerful and flexible champion who shines in both teamfights and poke-heavy lanes. With the right build, runes, and a strong understanding of her combos, you can control fights, peel for allies, and keep your team alive while dishing out consistent damage. Whether you’re playing her as a support or mid laner, mastering Seraphine’s kit will let you make a huge impact in every match and turn the tide of battle with just one well-timed ultimate.