10 Best Champion Combos in League of Legends

Some champions in League of Legends are strong on their own, but when you pair them with the right partner, they become absolute monsters on the Rift. Certain duos have perfect synergy — they chain CC flawlessly, explode targets instantly, or set up teamfights so easily that the enemy team can barely react. In this list, we’re breaking down the 10 best champion combos in League of Legends, the pairs that consistently dominate lanes, snowball early leads, and bring unstoppable pressure from start to finish.

#10: Jhin & Xerath

Jhin and Xerath are the perfect long-range poke duo that turns the bot lane into a nightmare. Xerath softens enemies from a distance with constant spell pressure, forcing them to burn potions and play scared, and the moment someone missteps, Jhin follows up with deadly precision. His W root becomes almost guaranteed after Xerath lands any form of poke or stun, which then sets up a clean fourth-shot burst or an all-in with his ultimate. This combo controls the lane effortlessly, punishes every positioning mistake, and can snowball simply by chunking opponents until they’re too low to even walk up to farm.

#9: Lee Sin & LeBlanc

Lee Sin and LeBlanc are one of the deadliest mid-jungle assassin duos you can play, built entirely around explosive picks and constant pressure. LeBlanc brings instant burst and reliable crowd control with her chains, giving Lee Sin an easy setup for his damage combo or a clean angle for an Insec kick. Together, they move fast, dive even faster, and punish anyone who steps too far forward in mid. Their ability to disappear into fog, hit hard, and escape before the enemy can react makes them perfect for snowballing games early, taking over river fights, and controlling objectives through sheer threat alone.

#8: Hecarim & Yuumi

Hecarim and Yuumi are the definition of chaos unleashed. Once Yuumi hops onto Hecarim, he becomes a speeding battering ram with endless sustain, extra mobility, and bonus damage that turns every engage into a full-on wipe. Yuumi’s heals and movement speed buffs let Hecarim dive deeper than almost any champion in the game, while her ultimate sets up perfect fear chains after Hecarim’s devastating charge. This combo thrives on nonstop aggression—hard engages, mid-game skirmishes, and explosive teamfight initiations that instantly break enemy formations. When these two are ahead, the enemy team barely has time to react before they’re trampled.

#7: Lillia & Miss Fortune

Lillia and Miss Fortune make teamfights feel completely unfair thanks to how well their kits lock enemies in place and punish grouped opponents. Lillia’s ability to tag multiple targets with her abilities sets up her Sleep perfectly, creating the ideal window for Miss Fortune to unleash Bullet Time without interruption. Once the entire enemy team is drifting off to sleep, Miss Fortune’s ultimate can shred through their health bars before they even wake up. Even outside full 5v5 fights, this duo excels in skirmishes—Lillia provides constant mobility, poke, and CC, while Miss Fortune brings explosive damage that punishes anyone caught by Lillia’s slows or Sleep. When played together, they turn every dragon fight or jungle choke point into a highlight reel.

#6: Twisted Fate & Nocturne

Twisted Fate and Nocturne are one of the most iconic global-pressure duos in League of Legends, turning the entire map into a danger zone the moment they both hit level six. Nocturne’s Paranoia shuts down vision and isolates targets, while Twisted Fate’s Destiny lets him instantly collapse on anyone Nocturne dives. The combo is simple but brutally effective: Nocturne flies in first, the enemy panics in darkness, and Twisted Fate appears out of nowhere with a Gold Card to guarantee the kill. This pair snowballs side lanes insanely fast, shuts down scaling picks, and forces the enemy team to play glued together just to survive. When they sync their ultimates, no lane is safe and every overextended champion becomes a free pick.

#5: Alistar & Ziggs

Alistar and Ziggs make a surprisingly terrifying kill-and-siege combo that dominates chaotic skirmishes and melts towers. Alistar brings the hard engage and peel—Headbutt and Pulverize create the perfect setup—while Ziggs follows up with massive burst from a safe distance. The moment Alistar finds a knock-up, Ziggs turns the fight into a bombing run, chunking the enemy team before they even react. And if they somehow survive? Ziggs’ Mega Inferno Bomb finishes the job. Outside of fights, this duo is just as oppressive: Alistar zones anyone who tries to defend, while Ziggs shreds turret plates with Satchel Charge. Together, they control space, win poke wars, and snowball objectives faster than most bot-lane pairings.

#4: Lissandra & Viego

Lissandra and Viego are one of those duos that feel unfair once they get rolling because everything about their kits perfectly complements each other. Lissandra brings instant lockdown, huge zone control, and guaranteed picks — the moment she presses W or R, someone on the enemy team is frozen in place with nowhere to go. And that’s exactly what Viego wants. Every time Lissandra catches a target, Viego gets a free moment to slide in, burst them down, and start chaining resets. Once the first enemy falls, the fight snowballs instantly as Viego takes over possession after possession. Lissandra also thrives in messy skirmishes where she can frontline, peel, and disrupt, which gives Viego the space he needs to keep diving. If you want a mid/jungle duo built for guaranteed picks, relentless dive pressure, and unstoppable teamfight momentum, this pairing is easily one of the strongest in the game.

#3: Blitzcrank & Veigar

Blitzcrank and Veigar are a classic “one mistake and you’re dead” combo that punishes anyone who dares to step even an inch too far forward. The moment Blitz lands a hook, the target isn’t just pulled out of position — they’re dragged straight into Veigar’s Event Horizon, guaranteeing a stun the second they land. From there, it’s basically a free kill every single time. Veigar gets to drop his entire burst rotation on a completely immobile target, stacking AP for free, while Blitzcrank zones out the rest of the enemy team with knock-ups and silence. This combo dominates lane, destroys mid-game picks, and completely controls objectives because no one wants to walk near fog when a hook into a cage means instant deletion. If you love creating pressure and forcing enemies to play terrified, Blitzcrank and Veigar are one of the most lethal duos you can run.

#2: Caitlyn & Lux

Caitlyn and Lux are the definition of lane bullying — a duo built entirely around nonstop poke, long-range picks, and forcing enemies to play miles away from the wave. Lux’s snare is the key to the whole combo. The moment she lands a Light Binding, Caitlyn gets to drop a free headshot, place a trap directly under the rooted target, and follow up with her full damage combo without any chance of retaliation. It’s an effortless chain of CC into burst that can delete squishier champs before they even think about flashing. Outside of picks, both champions pressure the lane constantly with long-range poke, making it almost impossible for the enemy bot lane to walk up for CS without losing half their HP. Add their ability to siege turrets safely from afar and you get one of the strongest early-to-mid game duos in the game — a pairing that snowballs fast and forces the enemy to respect every single skill shot.

#1: Nami & Lucian

Nami and Lucian are one of the strongest early-game kill lanes in League of Legends — a duo that turns every small trade into a winning all-in. The combo works so well because Nami’s E and W instantly supercharge Lucian’s kit. Every time she buffs him, Lucian gets empowered autos and double-shot procs that hit like a truck, letting him dash in with Relentless Pursuit and shred opponents before they can react. Her heal-and-damage bounce also keeps him healthy while whittling down the enemy lane, creating nonstop pressure from level two onward. Once Nami lands a bubble or slows someone with Tidecaller’s Blessing, Lucian can follow up with a full rotation that almost always forces a flash or secures a kill. Together they dominate short trades, control the lane tempo, and snowball incredibly fast — which is why this duo remains one of the scariest and most reliable bot lane combos in the entire game.

Conclusion

These ten champion combos show just how powerful good synergy can be in League of Legends. When two kits naturally boost each other, even the smallest opening can snowball into a game-winning fight. Whether it’s long-range poke duos, deadly pick setups, or lane bullies that take over from level two, the right pairing can completely change how you play the map. If you want to climb faster, try out some of these combos with a friend or duo partner — once you feel how well they flow together, you’ll see why these pairs stand out as some of the strongest and most reliable combos in the game.