Wild Rift Vayne Guide: Best Build, Runes, Items, Combos

Vayne is one of the deadliest ADCs in Wild Rift, known for her mobility, true damage, and insane late-game carry potential. Whether you’re chasing down enemies with her Tumble or melting tanks with Silver Bolts, mastering Vayne takes skill and precision. In this guide, we’ll cover the best Vayne build, ideal runes, must-have items, and powerful combos to help you dominate the Rift and carry your team to victory.

Vayne Abilities Overview In Wild Rift

Vayne’s kit in Wild Rift is all about mobility, chasing down targets, and dealing heavy true damage. Her Passive – Night Hunter grants bonus movement speed when moving toward enemy champions, helping her stick to targets. First Ability – Tumble is a short dash that also empowers her next basic attack, perfect for repositioning and poking. Second Ability – Silver Bolts adds true damage every third consecutive hit on the same target, making her a tank shredder. Third Ability – Condemn knocks enemies back and stuns them if they hit a wall, which can secure kills or peel for herself. Finally, her Ultimate – Final Hour boosts her attack damage, enhances her Tumble with invisibility, and makes her a nightmare to deal with during fights.

How To Play Vayne In Wild Rift

Best Summoner Spells For Vayne

The best summoner spells for Vayne in Wild Rift are Flash and Heal. Flash is crucial for repositioning, escaping danger, or chasing down kills—especially since Vayne relies heavily on positioning to stay alive and maximize damage. Heal gives her sustain in trades and team fights, plus the bonus movement speed can help her kite enemies more effectively. If you’re playing in a duo lane with a support that already brings Heal, consider swapping it for Barrier for extra survivability against burst damage.

Best Runes For Vayne

The best runes for Vayne in Wild Rift focus on boosting her dueling power, sustain, and mobility:
• Keystone: Conqueror – Perfect for extended trades, stacking damage quickly as Vayne weaves in auto attacks and abilities.
• Domination: Brutal – Gives flat AD and armor penetration early on, helping Vayne hit harder in lane.
• Resolve: Hunter – Titan – Grants bonus health and tenacity with takedowns, helping her stay mobile and survive crowd control.
• Inspiration: Sweet Tooth – Increases healing from Honeyfruits and gives gold, letting Vayne scale faster.

This rune setup makes Vayne stronger in the early game while scaling into a late-game monster, perfectly complementing her high-risk, high-reward playstyle.

Best Build For Vayne

The best build for Vayne in Wild Rift maximizes her attack speed, damage, and survivability to shred through tanks and outplay fights. Start with Blade of the Ruined King for strong on-hit damage and lifesteal, then rush Phantom Dancer for critical chance, attack speed, and a clutch shield. Follow up with Infinity Edge to boost crit damage, and Wit’s End for magic resist and more on-hit burst. Add Guardian Angel for a second life in late-game teamfights. Finish with Gluttonous Greaves (with Stasis or Quicksilver Enchant) for sustain and utility. This build keeps Vayne deadly and hard to kill, letting you 1v9 games when positioned well.

Best Combos To Learn For Vayne

The best combos to learn for Vayne in Wild Rift focus on using her mobility and damage to outplay enemies and secure kills. Start with Tumble (1st skill) into a basic attack to quickly trigger her Silver Bolts (2nd skill), then weave in two more auto-attacks to proc the true damage. When chasing or kiting, use Tumble → AA → AA and repeat to burst enemies while staying mobile. In tight spots, use Condemn (3rd skill) right after a Tumble to reposition and knock enemies into a wall for the stun. During teamfights or ganks, activate Final Hour (Ultimate) before engaging, then Tumble → AA → Condemn into a wall for a quick pick. Mastering these combos will let you duel, kite, and carry fights with Vayne’s late-game power.

Conclusion

Vayne is one of the strongest late-game champions in Wild Rift when played with precision and smart positioning. With the right runes, build, and a good understanding of her combos, you can melt tanks, kite bruisers, and carry teamfights with ease. Mastering her mechanics and knowing when to engage or back off makes all the difference. Whether you’re climbing solo queue or dominating in duo lane, this Vayne guide gives you everything you need to maximize her potential and become a true threat in every match.