Wild Rift Twitch Guide: Best Build, Runes, Items, Combos

Twitch is a deadly marksman in Wild Rift known for his stealth, insane attack speed, and ability to melt through enemy teams with well-timed ambushes. Whether you’re sneaking into the backline for a surprise triple kill or shredding tanks with your ultimate, Twitch brings relentless pressure to every lane and late-game team fight. In this guide, we’ll break down the best build, runes, items, and combos to help you master Twitch and dominate your ranked matches.

Twitch Abilities Overview In Wild Rift

Twitch’s abilities in Wild Rift revolve around stealth, poison, and high burst damage from surprise attacks. His passive, Deadly Venom, applies true damage over time whenever he auto-attacks an enemy. His first ability, Ambush, grants him camouflage and a burst of attack speed when breaking stealth, making it perfect for flanking or escaping. His second ability, Venom Cask, slows enemies in an area and adds poison stacks, setting them up for more damage. Contaminate, his third ability, detonates all poison stacks on nearby enemies to deal instant burst damage. Finally, his ultimate, Spray and Pray, massively increases his attack range and gives his auto-attacks piercing damage, allowing him to wipe out grouped enemies with rapid-fire shots.

How To Play Twitch In Wild Rift

Best Summoner Spells For Twitch

The best summoner spells for Twitch in Wild Rift are Flash and Heal. Flash gives Twitch a much-needed escape tool or aggressive repositioning during fights, especially since he lacks mobility once out of stealth. Heal provides sustain during trades and team fights, helping him survive burst damage and kite enemies. This combo ensures Twitch can engage safely, escape sticky situations, and stay alive long enough to dish out his full damage.

Best Runes For Twitch

The best runes for Twitch in Wild Rift focus on boosting his damage output while giving him the sustain and mobility he needs to thrive in fights. First Strike is the top keystone since Twitch can easily trigger it with his stealth opener and burst enemies before they react, giving him bonus gold and extra damage. For secondary runes, go with Brutal to boost early-game damage, Regeneration for better sustain during lane phase, and Sweet Tooth for extra healing and gold from honeyfruits. This setup helps Twitch snowball quickly while staying healthy and dangerous throughout the game.

Best Build For Twitch

The best build for Twitch in Wild Rift focuses on maximizing his attack speed, critical strike, and stealth burst potential. Start with Kraken Slayer for consistent true damage on every third hit, then go for Runaan’s Hurricane to spread your poison and ramp up damage in team fights. Follow up with Infinity Edge to boost your crits, and Phantom Dancer for even more attack speed and survivability. Add Mortal Reminder if the enemy has heavy healing, or Guardian Angel for late-game protection. For boots, take Gluttonous Greaves and upgrade to Stasis Enchant for clutch survivability in critical moments.

Best Combos To Learn For Twitch

The best combos to learn for Twitch in Wild Rift revolve around stealth, positioning, and maximizing poison stacks. A solid combo starts with Ambush (1) to go invisible and reposition, then open with a basic attack to trigger his attack speed bonus. Immediately follow up with more autos to apply poison stacks, and once you have at least 4–5 stacks, activate Contaminate (3) to burst them down. If you’re entering a teamfight, use Spray and Pray (Ultimate) during Ambush to surprise enemies with long-range piercing shots. A deadly combo is: Ambush → Basic Attacks → Spray and Pray → Contaminate, which melts squishy targets fast.

Conclusion

Twitch is one of the deadliest ADCs in Wild Rift when played with the right build, runes, and combo timing. His stealth-based playstyle makes him perfect for ambushing enemies and dominating late-game fights. By mastering his combos and positioning, you can carry games with ease and catch opponents off guard. Whether you’re looking to climb solo queue or just have fun melting enemies with Spray and Pray, Twitch is a great pick when played smart and aggressively.